Engagement of distinct epitopes on CD 43 induces different co‐stimulatory pathways in human T cells

Engagement of distinct epitopes on CD43 induces different co‐stimulatory pathways in human T cells

Co-receptors, being either co-stimulatory or co-inhibitory, play a pivotal role in T-cell immunity. Several studies have indicated that CD43, one of the abundant T-cell surface glycoproteins, acts not only as a potent co-receptor but also as a negative regulator for T-cell activation. Here we demonstrate that co-stimulation of human peripheral blood (PB) T cells through two distinct CD43 epitop...

This information is current as Through Distinct Pathways CD 81 and CD 28 Costimulate T Cells

Through Distinct Pathways CD 81 and CD 28 Costimulate T Cells

CD28 costimulatory signal induces protein arginine methylation in T cells

Protein phosphorylation initiates signal transduction that triggers lymphocyte activation. However, other posttranslational modifications may contribute to this process. Here, we show that CD28 engagement induced protein arginine methyltransferase activity and methylation on arginine of several proteins, including Vav1. Methylation of Vav1 and IL-2 production were reduced by inhibiting S-adenos...

The effects of Cyclosporine A and azathioprine on human T cells activated by different costimulatory signals

Immunosuppression is an important treatment modality in transplantation and human diseases that are associated with aberrant T cell activation. There are considerable differences regarding the cellular processes targeted by the immunosuppressive drugs that are in clinical use. Drugs like azathioprine (Aza) mainly act by halting proliferation of fast dividing cells, whereas others like cyclospor...